Heart Disease Prevention - What Is Metabolism And How To Boost It To Lose Weight?

Undoubtedly, the best way to burn fat and speed up metabolism is to carry out more physical activity and exercises like regular aerobic exercise, strength training and lifestyle activities. But there are other ways of boosting the metabolism by just making simple changes to the daily routine. Click the following link to find out more!

Heart Disease Prevention - What Is Metabolism And How To Boost It To Lose Weight?

How Does Sleep Deprivation Affect Weight And Health?

When one has insufficient sleep during the night, he or she might feel sleepiness the next morning that might cause accidents either on the road or at work. Lack of sleep might also impair judgment and make one forgetful.

During the EPI/Lifestyle 2015 Scientific Sessions organized by the American Heart Association (AHA) held between March 3 and 6 in San Diego, researchers from the University of Bristol in the United Kingdom and Weill Cornell Medical College in Qatar reported that people who lose as little as 30 minutes of sleep on a weekday have changes in their metabolism that might make them gain weight and put them at risk of getting diabetes.

522 patients who had just been diagnosed with Type-2 diabetes were studied. They were taking part in a different study meant to determine whether exercise and diet would help and as part of the study, the volunteers also filled out a sleep diary.

Patients who had 30 minutes less than the recommended 8 hours a night were more likely to be obese and also had insulin resistance that could lead to diabetes. After a year, for every 30 minutes under 8 hours, the rate of obesity went up by 17 percent and the rate of insulin resistance, a key problem of diabetes, went up 39 percent.

In another study that was published online February 19, 2015 in the journal ‘Diabetologia’, researchers from the University of Chicago revealed the reasons why getting too little sleep might raise the risk of diabetes. According to them, lack of sleep could lead to increased levels of substances known as fatty acids in the blood. As long as fatty acid levels remained high, the ability of insulin to regulate blood sugar levels was impaired.

The study was small and involved only 19 healthy men who aged between 18 and 30. They participated in 2 sleep scenarios. In one, they got a full night's sleep (about 8 hours a night) for 4 nights. In the other, they only got slightly more than 4 hours of sleep a night. After a few consecutive nights of getting too little sleep, the men's blood levels of fatty acids increased and stayed high for about 5 hours in the early morning hours. These levels usually peak and then drop overnight.

Overweight is undesirable as it is one of the key risk factors for heart disease and stroke, and so is diabetes. Fortunately, as the researchers suggested, high rates of obesity and diabetes could be reduced by something as simple as getting more sleep.

Is Obesity Hard-Wired in The Brain?

The escalating obesity rate has become a tricky issue for many countries. This is because obesity can eventually lead to development of many diseases, including heart disease, diabetes, hypertension (high blood pressure) and stroke. The expecting cost of dealing with these diseases can be huge, which will become a burden not only on the people but also on the government.

Many health experts have frequently blamed the modern lifestyle of overeating, inappropriate diet and lack of exercise as the cause of overweight and obesity. However, a study by the researchers from the University of Southern California, Los Angeles found that obesity might be hard-wired into the brain from birth so that some people are more prone to overweight than others.

The findings of an animal study, appearing on in the February 2008 issue of Cell Metabolism, showed that obese rats had faulty brain wiring that impaired their response to the hunger-suppressing hormone leptin.

It seemed that appetite and obesity were built into the brain for obesity-prone rats, according to the researchers. The neurodevelopment differences in these animals could be seen as early as the first week. Such results showed that obesity could be wired into the brain from early life.

Leptin, produced by fat tissue, plays a central role in fat metabolism by acting as a signal to the brain about the body's energy status. Though scientists are still not clear about its role in weight regulation, they are aware that the brain calibrates the requirement for food intake partly based on leptin levels.

Learnt from previous research that the brains of obesity-prone rats were insensitive to these leptin signals, the researchers looked for brain abnormalities that could explain this.

In the study, they found defects in the brain circuits that relay leptin signals throughout the hypothalamus. Hypothalamus is the brain’s central switchboard for regulating conditions in the body.

The findings showed that exercising and eating right might improve the rat’s condition, but the propensity to gain weight could not be reversed.

The researchers also pointed out that if the findings are replicated in humans, then those individuals who are genetically predisposed to obesity as a result of their brains’ configuration should carefully pay attention to diet and energy balance.

Meanwhile, they also cautioned that the general belief that weight regulation is all a matter of nutrition or lifestyle choices might not be helpful for people whose biology predisposes them to obesity.

Is The Number of Young Diabetics Rising in Asia?

Diabetes mellitus, more often referred to as diabetes, is a condition in which the body does not produce enough or properly respond to insulin. Being a hormone produced in the pancreas, insulin has the function of enabling cells to absorb glucose and turning it into energy. When a person has diabetes, the glucose will accumulate in the blood and this will eventually lead to various complications. For instance, diabetes has been identified as a risk factor for heart disease.

There is no doubt that diabetes has turned into a global problem. It is expected that the number of victims will grow from 240 million in 2007 to 380 million in 2025.

In Europe and North America, overweight and obesity have long been thought to lead to Type-2 diabetes. However, a study, published on May 27, 2009 in the Journal of American Medical Association, reported that the number of diabetics is rising in Asia affecting those who are relatively young and less likely to be struggling with obesity, unlike in the West.

Based on the figures from the International Diabetes Federation, more than 60 percent of diabetics will reside in Asia, the fastest growing region in the world. Countries with low- and middle-income will face the hardest hit. The number of diabetics will grow from 40 million to nearly 70 million in India; 39 million to 59 million in China; and 3.8 million to 7.4 million in Bangladesh.

While the trends of diabetes could be influenced from genetic makeup and cultural differences to smoking and degrees of urbanization, the most startling result was still related to body mass and age.

Despite lower obesity rate, the waistlines of Asian population keep expanding as a result of rapid economic development, changing diets and more sedentary lifestyle. Expanding waistline is considered to be harmful to diabetes. This is because fat around the abdomen stores excess energy and releases chemicals that control metabolism and use of insulin.

Although people across Asia generally have lower body mass index (BMI), which is the ratio of weight (kg) divided by the square of height (cm), they can have a similar or even higher chance of developing diabetes, according to the study.

Is Calorie-burning Fat Just a Myth?

Have you ever heard about “calorie-burning fat”? If not, you may wonder does it really exist or just a science fiction.

In reality, adults do have small blobs of metabolism-regulating “brown fat”, which scientists believe it exist only in babies and children. Such finding was announced in a study conducted by researchers from the Joslin Diabetes Center in Boston, Massachusetts.

The paper, published on in April 9, 2009’s issue of The New England Journal of Medicine, revealed that the brown fat or so-called good fat differs from white fat that makes up most body fat in such a way that the brown fat is active in burning calories and using energy. They also showed that the brown fat subsisted in adult humans and demonstrated, for the first time, that it is metabolically active.

According to the study, brown fat may have a role in regulating body weight metabolism. Therefore, by stimulating brown fat growth to control weight and improve glucose metabolism, the researchers believe that obesity, Type-2 diabetes and other metabolic disorders could be treated. Meanwhile, higher levels of brown fat might also help protect against obesity linked with aging.

By analyzing a database of 1,972 patients who had nuclear (PET) or X-ray (CT) imaging scans during a 3-year period for a variety of reasons, the researchers discovered that significant brown fat deposits in 7.5 percent of female patients and in over 3 percent of male patients. Most of the brown fat deposits were found in the patients' necks.

In the study, the tissue of 2 patients showing brown fat concentrations in their necks were tested and it was found that the cells had the protein UCP-1, which is unique to brown fat.

The study also found that the amount of brown fat presence depends on a variety of factors like age, glucose levels and, most importantly, level of obesity. For example, younger and thinner patients who had normal blood glucose levels had more brown fat, while brown fat was more active in cold weather as it helps in burning energy to produce heat.

It has been known that obesity, Type-2 diabetes and other disorders associated with obesity or overweight could eventually lead to heart disease. Such new discovery not only helps treat people with obesity but also helps them prevent heart disease.

How Does Fat Accumulation Link to Diabetes?

Being overweight or obese, one is at risk of developing diabetes. Like it or not, he or she will have a much higher chance of getting heart disease and other medical conditions.

A recent study by researchers from Erasmus Medical Centre-Sophia, Children's Hospital, Rotterdam, the Netherlands argued that the amount of fat accumulation of people have as they grow into adulthood would affect their risk of developing Type-2 diabetes.

They found that fat mass of a person in adulthood was the only factor significantly related to insulin sensitivity. It has been known that reduced insulin sensitivity is a precursor to diabetes. As such, parents should be aware of the risk of fat accumulation in their children, independent of birth size or growth childhood.

There was research suggesting that low birth weight was linked to increased risk of Type-2 diabetes. Yet there were others proposing that the acceleration in growth in people who were born small but attain normal adult size has harmful effects on metabolism. Nevertheless, it is still not clear if people who are born small and catch up in body size or those remain small throughout their lifetime are at greater risk of getting Type-2 diabetes.

Insulin sensitivity of 136 young men and women were examined in the study. The participants consists of 4 groups: some were born small for gestational age and remained short as adults; some were born small but reached normal height in adulthood; some were of normal size at birth but grew up to be short adults; and some were born at normal size and remained normal size as adults.

At the end of the study, researchers discovered that fat mass in adulthood was the only measurement that showed a significant link with the insulin sensitivity. The group of men and women, who were born small but caught up in body size as adults, had significantly lower insulin sensitivity than the control group.

A so-called ‘fat accumulation hypothesis’ was then proposed in March 2008 by the researchers stating that ‘an increased accumulation of fat during childhood, independent of birth size, will result in reduced insulin sensitivity.’ They also believed growth acceleration in height and weight as such is not a problem as long as a normal amount of fat is accumulated.

In conclusion, the researchers urge all individuals, regardless of their size at birth, should try to achieve or maintain a normal fat mass for their body size.

Another Way to Lose Weight – Nutrigenetic Diets

Most people are aware that the more weight they gain the higher chances that they might be short-listed as victims of heart disease, diabetes, stroke, and even certain types of cancer. Unfortunately, weight can still be accumulated in one’s body gradually and un-noticeably. Once one becomes overweight or even obese, it would be extremely difficult for him or her to lose the unwanted weight.

A recent study outlined a way to help overweight individuals lose weight and keep it off by using personalized diets based on the individual’s genetic makeup. The researchers from Sciona, the Boulder, a company based in Colorado, reported in online journal BioMed Central: Nutrition Journal in 2007 that people who went on ‘nutrigenetically tailored diets’ were more apt to stick to the diet, and had greater success in the long term.

The study was partially funded by Sciona, which makes the testing system used to develop a person's nutrigenetic diet.

In the study, the case histories of 50 'nutrigenetic' dieters were compared with those of 43 patients who did not receive a nutrigenetically tailored diet.

All of these patients were attending a weight loss clinic in Athens, Greece by following a traditional weight management program involving a Mediterranean diet with exercise and regular follow-up clinic visits. Nevertheless, the researchers modified the standard Mediterranean diet of the nutrigenetic group to tailor the genetic results of each patient.

There was no much difference between the 2 groups in term of the amount of weight loss. After about one year, the nutrigenetic dieters continued to lose weight but a slight average weight gain was observed among the traditional diet group.

After another 300 days, it was found that the nutrigenetic dieters were about 5 times more likely to have maintained their weight loss than were the traditional dieters, and the nutrigenetic dieters also had improvements in their blood sugar levels.

In conclusion, the researchers suggest that adding a genetic, personalized component to a weight loss program might improve motivation and compliance. Moreover, the personalized diet is more suitable as the content of macro- and micro-nutrients were optimized for an individual during a period when overall food consumption is reduced and energy expenditure increased.

Some People Are Prone To Be Obese From Birth!

Being a risk factor for heart disease, obesity is frequently associated with unhealthy lifestyle and diet, but a new study could have probably changed this perception.

A new animal study, conducted by the University of Southern California, Los Angeles and released on February 5, 2008 in the February issue of Cell Metabolism, revealed that obesity might be hard-wired into the brain from birth, and this will make some people to be more prone to put on weight than others do.

It seems that appetite and obesity are built into the brain. In the study, obese rats had faulty brain wiring that impaired their response to the hunger-suppressing hormone leptin. Leptin plays an imperative role in fat metabolism. Produced by fat tissue, it acts as a signal to the brain about the body's energy status. Although its role in weight regulation is still unclear, it is understood that the brain calibrates the need for food intake based in part on leptin levels.

Previous research had shown that the brains of obesity-prone rats were insensitive to these leptin signals, so the researchers looked for brain abnormalities that could explain this. They found defects in the brain circuits that relay leptin signals throughout the hypothalamus, which is the brain's central switchboard for regulating conditions in the body.

According to the researchers, the neurodevelopmental differences in these animals can be seen as early as the first week. The results show that obesity can be wired into the brain from early life. Exercising and eating right might improve the rats’ condition, but the findings suggest that the propensity to gain weight cannot be reversed.

If we replicate the findings in humans, then people should be careful about those one-size-fits-all approach weight management and weight loss, especially those individuals who are genetically predisposed to obesity because of the way their brains are configured.

Is Natural Products Harmful In Helping Weight Loss?

Many natural products contain bioactive substances that suppress appetite, stimulate metabolism, or induce water loss from the body.

One should note that though they are 'natural', it does not mean that they are not harmful.

The danger of using these products lies in fact that they are used without any medical supervision. Abuse cases on using natural products to help weight loss have been mentioned in newspapers at regular intervals.