Wednesday, November 24, 2010

Would Vitamin Help Diabetics?

For people who are unable to get adequate amount of vitamins and minerals from their diet, taking vitamin supplements could be a feasible alternative to help them meet their nutrition requirements. The elderly, strict vegetarians, people on low-calorie diets and those that are malnourished are some good examples of this type of people.

How about diabetics? Would vitamin help control their condition? Most health organizations associated with diabetes do not advocate using vitamins. In fact, they usually warn against using large doses of vitamins or supplements, which could possibly cause adverse side effects.

In April 28, 2010 edition of the Journal of the American Medical Association (JAMA), researchers from the University of Western Ontario and the Robarts Research Institute in London, Ontario reported that patients with diabetic nephropathy would suffer rapid deterioration of the kidneys if treated with high doses of Vitamin B. Moreover, these patients are likely to face a higher risk of heart attack and stroke than patients who took a placebo.

Diabetic nephropathy is a progressive kidney disease because of longstanding diabetes mellitus, and it is a prime indication for dialysis in many Western countries. Even with the many treatments available right now, about 40 percent of the 21 million Americans who have diabetes still develop diabetic nephropathy.

Prior observational studies have shown that there is an association between high concentrations of plasma total homocysteine and the risk of developing diabetic nephropathy, retinopathy, and vascular diseases, including myocardial infarction and stroke. B-Vitamin therapy using folic acid, Vitamin-B6 and Vitamin-B12 is known to be capable of lowering the plasma concentration of homocysteine.

With an aim to developing a new approach to treatment, the researchers conducted a study to see if B-Vitamin therapy would actually slow progression of diabetic nephropathy and prevent vascular events in 238 patients with Type-1 or Type-2 diabetes. Meanwhile, the placebo-controlled trial was carried out at 5 university medical centers in Canada between May 2001 and July 2007.

Patients were prescribed with single tablet of B-Vitamins with folic acid (2.5 mg/d), Vitamin-B6 (25 mg/d), and Vitamin-B12 (1 mg/d), or matching placebo. After an average period of 31.9 months, patients with Vitamin-B were found to have a faster rate of reduction of kidney filtering and so the kidney function, as compared with those on a placebo course. For patients with the diabetic nephropathy, the risk of heart attack and stroke were also higher than those who took placebo.

No comments:

Post a Comment