Tuesday, October 21, 2008

How Would Hostility Raise Heart Disease Risk?

Before we get into the topic, we need to understand 3 terms: free radical, antioxidant and oxidative stress. Let us look at how they are related.

Technically, oxidative stress is a condition, which occurs when production of free radicals in the human body exceeds the body's ability to neutralize and eliminate them. Free radicals would start chain reactions that disturb the body’s ability to neutralize them, hence resulting in tissue or cell damage. Oxidative stress has been associated with heart disease, cancer and other illnesses.

Antioxidants could stop these chain reactions by removing free radical intermediates and inhibit other oxidation reactions by being oxidized themselves. Antioxidant vitamins like vitamin C and E can help counteract oxidative stress. On the other hand, activities like smoking and pollution can actually increase it.

A study has indicated that hostility could raise a person’s risk of heart disease by depleting the level of certain heart-healthy antioxidants.

The researchers from the University of Minneapolis, who carried out the study, suggested that antioxidants could help explain why hostile individuals are more likely to smoke and drink, and poor diet and smoking can deplete antioxidants.

In their study, the researchers investigated 3,579 men and women of the age between 18 and 30 years old who were participating in the so-called Cardiovascular Risk Development in Young Adults study. Their levels of several different carotenoids and tocopherols (vitamin E) were measured.

It was found that people having high levels of hostility at the beginning of the study were more likely to have lower levels of several types of carotenoids 7 years later, but hostility did not predict levels of tocopherols or lycopene. The increased risk was found to be, nevertheless, small but significant.

Lifestyle factors such as diet, smoking and drinking probably play a part in explaining why hostility reduces levels of antioxidants, but the researchers are not clear whether the differences are importantly related to the risk of coronary heart disease. Therefore, further study is necessary.

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